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Cefpodoxime (brand names: Simplicef® and Vantin®) is a third-generation cephalosporin antibiotic used to treat skin infections in dogs. Bacteria susceptible to cefpodoxime include certain Staphylococcus and Pasteurella species, Streptococcus canis, E. coli, and certain bacteria causing urinary tract and respiratory infections.
The use of cefpodoxime in cats and for the treatment of urinary tract infections in dogs is considered off label (extra label). Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.
Cefpodoxime may cause the following side effects:
If these effects worsen, become severe, or continue, contact your veterinarian as soon as possible.
Serious adverse reactions associated with this drug may occur without warning and could, in rare cases, lead to death. If any of the following signs develop, stop giving cefpodoxime and contact your veterinarian immediately:
Drug sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
DO NOT USE cefpodoxime in pets that:
USE WITH CAUTION in pets that:
Certain medications may interact with cefpodoxime, so be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
In a pet with diabetes, cefpodoxime may interact with urine glucose tests and cause false-positive results.
Most overdoses of cefpodoxime cause diarrhea, vomiting, lack of appetite, and lethargy; however, some overdoses can be more serious. If you suspect an overdose and your pet is experiencing an adverse reaction, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jun 11, 2025.
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